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Lipoprotein(a)

Lipid Profile · also called Lp(a), Lipoprotein little a

What it measures

Lp(a) is an LDL-like particle with an extra protein, apolipoprotein(a). Its level is mostly genetically determined and it is an independent risk factor for heart attack, stroke and aortic valve stenosis.

Specimen and preparation

Specimen: Serum or lithium-heparin plasma
Tube: Gold top
Preparation: Fasting not required; usually measured once in adult life.

Reference range

Group	Range
Adult	<75 (<30) nmol/L (mg/dL)
High risk	>125 (>50) nmol/L (mg/dL)

Reference ranges differ between laboratories, methods and populations. Always use the range printed on your own lab report.

Causes of high values

Genetic predisposition
Chronic kidney disease
Menopause
Hypothyroidism

Causes of low values

PCSK9 inhibitors
Niacin
Severe liver disease

Method

Isoform-insensitive immunoturbidimetry, reported in nmol/L

Good to know

Conversion between mg/dL and nmol/L is not exact because particle size varies. Useful in premature cardiovascular disease or family history.

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