MLT GlobeHIV-1/2 antigen/antibody combination test
Infectious Diseases · also called HIV combo, 4th generation HIV test, HIV screening
What it measures
Detects HIV-1 p24 antigen and antibodies to HIV-1 and HIV-2 in one assay. It is the recommended screening test and shortens the window period to about 2–6 weeks.
Specimen and preparation
- Specimen: Serum or plasma
- Tube: Gold top
- Preparation: Pre-test counselling and informed consent as per local policy.
Reference range
| Group | Range |
|---|---|
| All | Non-reactive |
Reference ranges differ between laboratories, methods and populations. Always use the range printed on your own lab report.
Causes of high values
- HIV-1 or HIV-2 infection (requires confirmation)
- Acute HIV infection (p24 antigen positive)
- False positive (rare; confirm)
Method
CLIA/ECLIA 4th-generation immunoassay; rapid tests for screening
Good to know
Reactive results are confirmed with a differentiation assay and/or HIV-1 RNA following the national testing algorithm.
Related tests
📱 Practise with a timer, track your score and earn certificates in the free MLT Globe app – Google Play or practise online.