Hepatitis B core total antibody (anti-HBc total)

What it measures

Detects IgG and IgM antibodies to HBV core antigen. It shows exposure to HBV at any time, past or present, and is not produced by vaccination.

Specimen and preparation

• Specimen: Serum or plasma
• Tube: Gold top

Reference range

Reference ranges differ between laboratories, methods and populations. Always use the range printed on your own lab report.

Causes of high values

• Past resolved infection (with anti-HBs)
• Current acute or chronic infection (with HBsAg)
• Isolated anti-HBc: occult HBV, remote infection or false positive

Method

CLIA/ECLIA or ELISA

Good to know

Positive patients starting chemotherapy, rituximab or immunosuppression need HBV reactivation monitoring or prophylaxis.

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