Anti-double-stranded DNA antibody (anti-dsDNA)

What it measures

Detects antibodies against native DNA, which are highly specific for systemic lupus erythematosus. Levels often track disease activity, particularly lupus nephritis.

Specimen and preparation

• Specimen: Serum
• Tube: Gold top

Reference range

Reference ranges differ between laboratories, methods and populations. Always use the range printed on your own lab report.

Causes of high values

• Systemic lupus erythematosus
• Active lupus nephritis (rising titre)
• Some drug reactions (anti-TNF therapy)

Method

Crithidia luciliae IFA, ELISA/CLIA, or Farr assay

Good to know

Rising anti-dsDNA with falling C3/C4 suggests an impending lupus flare.

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