MLT GlobeAnti-cyclic citrullinated peptide antibody (anti-CCP)
Arthritis & Autoimmune · also called ACPA, Anti-citrullinated protein antibody
What it measures
Detects antibodies to citrullinated proteins, highly specific for rheumatoid arthritis. It can appear years before symptoms and predicts erosive disease.
Specimen and preparation
- Specimen: Serum
- Tube: Gold top
Reference range
| Group | Range |
|---|---|
| Adult | < 17 (kit dependent) U/mL |
Reference ranges differ between laboratories, methods and populations. Always use the range printed on your own lab report.
Causes of high values
- Rheumatoid arthritis (specificity about 95%)
- Early or pre-clinical RA
- Occasionally psoriatic arthritis or other connective tissue disease
Method
ELISA or CLIA
Good to know
Positive anti-CCP with RF gives the strongest support for RA.
Related tests
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