MLT GlobeHome › Techniques › Lepromin test
Lepromin test
Immunology & Serology
Principle
Lepromin (heat-killed M. leprae) injected intradermally tests cell-mediated immunity to leprosy. It is not diagnostic; it helps classify the type of leprosy.
Reading
- Early (Fernandez) reaction: at 48 h, like a tuberculin reaction.
- Late (Mitsuda) reaction: nodule at 3–4 weeks.
Interpretation
- Positive in tuberculoid leprosy (good cell-mediated immunity)
- Negative in lepromatous leprosy (poor cell-mediated immunity)
Note
Rarely used today; mainly a teaching and exam topic.
📱 Practise with a timer, track your score and earn certificates in the free MLT Globe app – Google Play or practise online.