MLT GlobeBlood Banking: Donor selection & processing – page 2
75 Blood Banking MCQs on Donor selection & processing with answers and explanations.
A donor's red cells are negative with anti-D at immediate spin but positive in the indirect antiglobulin weak D test. The unit must be labeled:
Donor units must be tested for weak D, and units with weak D are labeled D-positive. Weak D cells could immunize a D-negative recipient.
During donation, a swelling appears at the needle site. What is the correct action?
A hematoma means blood is leaking into tissues. The collection is stopped, the needle removed, and firm pressure with a cold pack applied.
After donating whole blood, a donor should be advised to:
Extra fluids help restore blood volume. Avoiding heavy exertion lowers the risk of fainting and of bleeding at the needle site.
According to WHO, the safest source of blood is:
WHO recommends collecting all blood from regular voluntary unpaid donors, who have the lowest rates of transfusion-transmissible infections.
The 'window period' of an infection in blood donors is the time when:
Early after infection, the agent may be in the blood before antibodies or antigens reach detectable levels. NAT shortens this window but does not remove it.
The donor health questionnaire is mainly used to:
The questionnaire finds donors who could be harmed by donating or whose blood could harm a recipient, for example through recent risk behavior or illness.
Blood donated by a relative or friend for a specific named patient is called a:
A directed donation is intended for a named recipient. An autologous donation is the patient's own blood.
Apheresis is a collection method in which:
An apheresis machine draws blood, separates out the chosen component (such as platelets or plasma) and returns the rest to the donor.
Until all donor screening tests are completed and negative, collected units are kept:
Untested units are quarantined so they cannot be issued by mistake. They are released only after all mandatory tests are negative and labeling is complete.
Which condition rules out collecting a patient's own blood for later autologous transfusion?
Bacteraemia risks bacterial growth in the stored unit. Pre-deposit weeks ahead, adequate haemoglobin and elective surgery are standard requirements for autologous donation.
A female donor is being screened. Under AABB criteria, what is the lowest acceptable haematocrit?
AABB requires Hb ≥12.5 g/dL or Hct ≥38% for female donors (≥13.0 g/dL or ≥39% for males) to protect the donor from anaemia.
Which donor can be accepted without deferral?
Toxoid and inactivated vaccines need no deferral if the donor is well. Post-exposure rabies vaccination defers for a year; active TB and recent syphilis also defer.
Which vaccine requires a donor deferral of about 4 weeks?
Live attenuated vaccines such as rubella or varicella need about 4 weeks' deferral because of transient viraemia. Killed, toxoid and recombinant vaccines need none if the donor is well.
Which donor can be accepted and does not need deferral?
Recombinant HBV vaccine without known exposure needs no deferral. Uncontrolled seizures, cardiac disease and fever defer to protect donor or recipient.
A healthy donor weighs 60 kg. What is the largest whole blood volume (including test samples) that may be collected?
The maximum collection is 10.5 mL/kg of body weight, including samples: 60 × 10.5 = 630 mL. 525 mL is the limit for a 50 kg donor.
In copper sulfate screening, a drop of donor blood sinks in a solution with specific gravity 1.053. This means:
A specific gravity of 1.053 corresponds to hemoglobin of about 12.5 g/dL. A drop that sinks is denser than the solution, so the donor meets the requirement; a floating drop fails.
A donor took aspirin 24 hours ago. Which statement is correct?
Aspirin irreversibly inhibits platelet cyclooxygenase. Whole blood donation is allowed, but plateletpheresis requires 2 full days after the last dose, and whole-blood platelets should not be the only platelet source.
Which medication leads to the LONGEST donor deferral because it is teratogenic and persists in the body?
Acitretin requires a 3-year deferral. Dutasteride needs 6 months, while finasteride and isotretinoin need about 1 month.
A donor reports receiving human pituitary-derived growth hormone as a child. What is the correct decision?
Pituitary-derived growth hormone has transmitted Creutzfeldt-Jakob disease, so recipients are deferred indefinitely. Recombinant growth hormone does not carry this risk.
A nurse received hepatitis B immune globulin (HBIG) after a needlestick injury. How long is she deferred from donation?
HBIG is given after possible HBV exposure, and it may also mask early infection. The donor is deferred for 12 months from the exposure.