MLT GlobeBasic Pathology: Infections & environmental pathology
4 Basic Pathology MCQs on Infections & environmental pathology with answers and explanations.
A stone-cutter develops chronic inflammation and fibrosis of the lung after years of inhaling dust. Which exogenous agent is most likely responsible?
Answer: D. Silica
Silica particles are toxic to macrophages and cause persistent inflammation and fibrosis (silicosis). Pure carbon is largely inert (anthracosis).
ID LG-PAT-0050 · Found a mistake? Report it
Common skin warts (verrucae) are caused by:
Answer: B. Human papillomavirus
Low-risk HPV types cause benign squamous papillomas (warts). EBV, HHV-8 and HTLV-1 are linked to lymphomas, Kaposi sarcoma and ATLL.
ID LG-PAT-0284 · Found a mistake? Report it
In a coal miner's lung with anthracotic nodules, inhaled coal dust is taken up and retained mainly by:
Answer: A. Macrophages
Alveolar and interstitial macrophages phagocytose carbon particles and carry them to lymphatics; dust-laden macrophages stimulate fibroblasts, causing fibrosis in pneumoconiosis.
ID LG-PAT-0620 · Found a mistake? Report it
Which bacterial product is a classic example of a superantigen?
Answer: D. Toxic shock syndrome toxin-1 of Staphylococcus aureus
TSST-1 and staphylococcal enterotoxins are secreted protein superantigens. LPS is an endotoxin acting via TLR4; peptidoglycan and capsules are not superantigens.
ID LG-PAT-0584 · Found a mistake? Report it
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