MLT GlobehCG as a tumour marker
Tumor Markers · also called Total hCG, β-hCG (oncology)
What it measures
Total hCG (intact hCG plus free beta subunit) is produced by trophoblastic and some germ-cell tumours. It is used for diagnosis, staging and follow-up of testicular cancer and gestational trophoblastic disease.
Specimen and preparation
- Specimen: Serum or lithium-heparin plasma
- Tube: Gold top
Reference range
| Group | Range |
|---|---|
| Adult male / non-pregnant female | <5 IU/L |
Reference ranges differ between laboratories, methods and populations. Always use the range printed on your own lab report.
Causes of high values
- Choriocarcinoma and molar pregnancy
- Seminoma and non-seminomatous germ-cell tumours
- Some lung, gastric and pancreatic cancers
- Pregnancy (must be excluded)
- Hypogonadism (low-level pituitary hCG)
Method
Chemiluminescent immunoassay detecting intact hCG and free β-subunit
Good to know
Use with AFP and LDH (see LDH under Liver Function) for testicular cancer staging. See beta-hCG under Hormones & Fertility for pregnancy use.
Related tests
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