Fecal calprotectin

What it measures

Measures a neutrophil protein in stool that reflects intestinal inflammation. It helps separate inflammatory bowel disease from irritable bowel syndrome and monitors IBD activity.

Specimen and preparation

• Specimen: Stool
• Tube: Stool top
• Preparation: Avoid NSAIDs for 2 weeks if possible; single random sample.

Reference range

Reference ranges differ between laboratories, methods and populations. Always use the range printed on your own lab report.

Causes of high values

• Active Crohn's disease or ulcerative colitis
• Infectious gastroenteritis
• NSAID enteropathy
• Colorectal cancer, polyps

Method

ELISA, immunoturbidimetry or quantitative rapid test

Good to know

Levels are physiologically higher in infants and young children.

Related tests