MLT GlobeEstimated glomerular filtration rate (eGFR)
Kidney Function · also called GFR, CKD-EPI eGFR
What it measures
eGFR is calculated from serum creatinine (and/or cystatin C), age and sex to estimate how much blood the kidneys filter per minute. It is used to stage chronic kidney disease and guide drug dosing.
Specimen and preparation
- Specimen: Serum or lithium-heparin plasma
- Tube: Gold top
- Preparation: Not valid during rapidly changing kidney function (acute kidney injury).
Reference range
| Group | Range |
|---|---|
| Adult | ≥90 mL/min/1.73 m² |
| CKD stage 3a | 45–59 mL/min/1.73 m² |
| Kidney failure (stage 5) | <15 mL/min/1.73 m² |
Reference ranges differ between laboratories, methods and populations. Always use the range printed on your own lab report.
Causes of high values
- Pregnancy (hyperfiltration)
- Early diabetic kidney disease
- Low muscle mass overestimates GFR
Causes of low values
- Chronic kidney disease
- Acute kidney injury
- Normal ageing
- Heart failure and hypoperfusion
Method
Calculated: CKD-EPI 2021 race-free equation; Schwartz bedside formula in children
Good to know
CKD needs eGFR <60 for over 3 months or markers of kidney damage such as albuminuria. Combined creatinine–cystatin C equations are the most accurate.
Related tests
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