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Anti-Müllerian hormone (AMH)

Hormones & Fertility · also called Müllerian-inhibiting substance, MIS

What it measures

AMH is produced by small growing ovarian follicles and reflects the remaining egg supply (ovarian reserve). It predicts response to IVF stimulation and supports the diagnosis of PCOS.

Specimen and preparation

Specimen: Serum or lithium-heparin plasma
Tube: Gold top
Preparation: Can be taken on any day of the cycle.

Reference range

Group	Range
Female 25–30 years	1.5–7.0 (approx.) ng/mL
Female 35–40 years	0.7–4.0 (approx.) ng/mL
Low reserve	<1.0 ng/mL

Reference ranges differ between laboratories, methods and populations. Always use the range printed on your own lab report.

Causes of high values

Polycystic ovary syndrome
Granulosa cell tumour
Young age

Causes of low values

Diminished ovarian reserve and approaching menopause
Ovarian surgery or chemotherapy
Hormonal contraception (temporarily)
Vitamin D deficiency (mild)

Method

Automated chemiluminescent immunoassay

Good to know

AMH predicts quantity, not quality, of eggs and does not predict natural fertility on its own. Ranges are age- and assay-specific.

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